Abstract
Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of B. ligulata. Bergenia species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus Bergenia. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus Bergenia that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. B. crassifolia alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on Bergenia species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare.
Highlights
The use of herbs for healing diseases and disorders can be dated back to at least 1500 BC [1].The traditional system of medicine (TCM) is a source of >60% of the commercialized drugs and is still used by the population in lower income countries for the cure of chronic diseases [2]
The botanical description of Bergenia species [31,32,33,34] is described in Supplementary Table S1
Bergenia species have been used in the traditional medicines for a long time
Summary
The use of herbs for healing diseases and disorders can be dated back to at least 1500 BC [1]. [synonym of B.anti-nociceptive, pacumbis] is an essential of an Ayurvedic antidiabetic, antilithiatic, anti-inflammatory, anti-HIV,ingredient and immunomodulatory formulation,. [synonym of B. pacumbis] is an essential ingredient dissolver in the indigenous system of medicine(Paashan [23,24]. Used as a kidney stone dissolver in the indigenous system of medicine [23,24] This drug has been ligulatain isancient reputedly known by other names including such as “Pashana”,. “Ashmabhid”, B. ligulata is“Parwatbhed”, reputedly known by other names as “Pashana”, The unavailability of a compendious review on bioactive molecules present in Bergenia [25]. Explicit knowledge on the traditional and medicinal importance and phytochemistry of the Bergenia species
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