Abstract
ABSTRACT The half-life of 7α-3H-dehydroepiandrosterone (DHEA), sodium 7α-3H-DHEA sulfate, and biosynthetic 7α-3H-DHEA sulfatide has been determined in guinea-pigs. Following the isolation of the individual compounds from plasma at various time intervals the half-life was found to be 2:30 and 3:00 minutes for DHEA sulfate, 7:15 and 8:15 minutes for free DHEA and 23 and 28 minutes for DHEA sulfatide. This data seems to support the hypothesis that steroid sulfatides may represent a labile transport form of steroid sulfates.
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