�ber krankheitsbedingte Ver�nderungen des Arbeitsstoffwechsels bei Ratten

Abstract

A method is described for estimating the gaseous metabolism in rats during work. The apparatus for performing work, the gas analyzer and the method of recording the results were modified in relation to the previous experimental method to determine the Recovery-metabolism. It is shown that a relationship exists between the speed on the running belt and O2-intake, and that the O2-intake of individual animal in consecutive experiments, under these conditions is relatively constant. Measurement of the gaseous-metabolism in rats during work offers a possibility to control the progress of the artificially produced diseases in the cardio-pulmonary system for month together. For this purpose it was necessary to establish a relationship between O2-intake during the recovery and the working phase, we called it “Relative O2-intake”. We found a higher “Relative O2-intake” in rats with advanced silicosis as well as with severe oleothorax. Moreover, they had a lower working capacity and dyspnea after work. Also most of the animals with experimental multiple embolism of the lungs produced by the intravenous injection of Mercury showed conformity between the “Relative O2-intake” dyspnea and the severity of the disease. But in this case, it was necessary also to consider the “Absolute O2-intake” In animals with chronic cortexon high pressure we likewise found a higher “Relative O2-intake” and working Dyspnea.