Abstract
The changes in the content of protein-bound SH (PSH) and nonprotein SH (NPSH) were determined during the development of DEN-rat hepatoma. The observed increase of NPSH is understood as a general phenomenon of chemically induced carcinogenesis. The SH-content of the soluble cell proteins (PSH) was significantly higher in the established tumor than in the normal liver. Furthermore, NPSH and PSH were determined after incubation of liver slices in 4-hydroxypentenal (ΗΡΕ). The NPSH of the normal liver as well as of the established hepatoma decreased by 50 percent. The PSH were much more resistant against ΗΡΕ decreasing only in the earlier stages of tumor development by 14%/g wet weight. No significant decrease in PSH/mg protein was observed. Similarly, the influence of ΗΡΕ on oxygen uptake of the normal liver and the hepatoma was determined: with normal liver no influence was observed, whereas a significant inhibition of 10% occurred only in the established tumor. These weak cytotoxic effects of ΗΡΕ on the DEN-hepatoma is related to the low malignancy of this tumor.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
