Über das verhalten der aktivität von serum-glutamato-xalacetat-transaminase, glutamat -pyruvat-transaminase und milchsäuredehydrogenase nach herzchirurgischen eingriffen

Abstract

The activity of SGOT, SGPT and LDH was determined in the serum of 55 patients with congenital heart diseases during a period of up to 12 days after heart surgery with extracorporeal circulation. Before the operation the enzyme activities were within the normal range. For a small group of patients the SGOT values increased to 1000 W.U. and higher, while in the majority of the cases activities of only up to 250 W.U. were found. The SGPT and LDH values remained mostly within the normal range, except in those cases where the SGOT values were high. Extracorporeal circulation and thoractomy have only a slight influence on the enzyme values. The increase in the activity does not depend on the severity of the operation, or on the duration of the extracorporeal circulation and cardiac arrest. Furthermore, it made no difference whether the operation was carried out under hypothermia or not. The duration of the operation, the duration of the anaesthesia, and the age of the patients had no effect on the changes in the activities. The causes of the increase in the activity of SGOT, SGPT and LDH, and the significance of the determinations for clinical diagnosis are discussed.