Abstract
Abstract3:3‐Disubstituted 2,6‐dioxo‐piperidine derivatives can be prepared by means of a Michael condensation of disubstituted acetic acid nitriles or acetic acid esters with acrylonitrile or acrylic acid esters, followed by saponification and ring closure. Of the aminoalkylated phenyl‐dioxo‐piperidines described the 3‐diethylamino‐ethyl‐3‐phenyl‐2,6‐dioxo‐piperidine has an especially strong and specific parasympathicolytic action. For purposes of comparison some pyrrolidine and hexamethyleneimine compounds were also prepared.
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