Abstract
The electrooxidation of benzylic C(sp3)-H bonds to produce hydrazones as an alternate for conventional pathways has an enormous dignity. Under the aegis of electricity, instead of hazardous metal catalysts and external oxidants, we unveil an electrochemical process for electrooxidation of various benzylic C(sp3)-H bonds in aqueous media in all pH ranges that subsequently produce hydrazones with further reactions. This electrooxidative reaction strategy provides an acceptable condition for synthesizing hydrazones with various functional groups in good efficiency and amenable to gram-scale synthesis. The electrochemical oxidation condition proves an excellent level of compatibility with super cheap electrolyte NaCl for the oxidation of benzylic C(sp3)-H position despite the highly oxidizable hydrazide group remaining intact in the reaction.
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