Abstract
N-aryl-1,3,4-thiadiazole derivatives were obtained by cyclization reaction of benzoic acid and N-arylthiosemicarbazides in the presence of phosphorous oxychloride (POCl3). FT-IR, 1H-NMR, and 13C-NMR, spectroscopic methods, and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized molecules was analysed with the 1,1-diphenyl-2-picryl hydrazyl (DPPH) free-radical–trapping process. IC50 values of these molecules were measured from 25.17 to 43.55 𝜇M. Among the synthesized compounds, compound II had the best antioxidant activity. Moreover, this work explained the structure-activity relationship of the obtained molecules with different substituents in radical trapping reactions.
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