Abstract
Brain homogenates of Sprague-Dawley rats subjected to ethanol inhalation for 19 days (mean blood ethanol of 258 ± 34 mg/100 ml) show 3-flunitrazepam binding virtually identical to that of ethanol-naive controls. GABA stimulation of 3-flunitrazepam binding is also nearly identical in these groups. These results suggest that the nature of the well recognized clinical interaction between benzodiazepines and ethanol is not mediated through primary binding sites for the benzodiazepines.
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