Benzocaine mesoporous silica nanoparticles/bio polysaccharides-based hydrogels loaded cotton bandage as a platform for topical anesthesia

Abstract

A new topical delivery system based on bio polysaccharides-based hydrogels for the local anesthetics drug benzocaine, was primed to circumvent its limited efficacy and short duration of action. The new system based on encapsulating the drug within nano-mesoporous silica then incorporating into different types of natural bio polysaccharides-based hydrogels including pullulan, dextran, acacia, and amino cellulose. Polysaccharides based hydrogels were prepared by grafting of polyacrylic acid onto the nature polysaccharides and then confirmed. Mesoporous silica nanoparticles (MSNs) were prepared and the drug benzocaine was encapsulating within it. The size, and morphology of prepared nanoparticles and the loaded nanoparticles were visualized using TEM and SEM analysis. Drug loaded nanoparticles were then incorporated into the prepared bio polysaccharides-based hydrogels and these composites were used to treat cotton gauze to use it as anesthetics topical bandage. The resistance to microbial growth of the prepared hydrogels were investigated using culture count method and the mechanical properties of the treated cotton gauze was tested. Drug loaded silica rented in polysaccharide-based hydrogel were conducted in invitro-release and ex vivo drug permeation study through isolated rat skin. In comparison to free drug aqueous suspension the hydrogel patches revealed enhanced amplified skin permeation sustained all over 24 h.