Abstract
The NaB–DNA adduction and its decay in mouse liver and kidney at environmental exposure doses were studied by accelerator mass spectrometry. The number of DNA adducts increased nonlinearly with increasing dose. At dose >500 μg/kg b.w., the DNA adducts level of kidney was higher than that of liver. After a single dose exposure, the DNA adducts level declined quickly to one-fourth within 1 d in liver and within 3 d in kidney, and then kept steady. Presumably, the initial fast decay process results from the metabolism via hippurate and the subsequent slow process from the easily persistent benzoyl glucuronide. Based on the low level of adducts formed and quick decrease of adducts, our experimental results are basically consistent with the previous safety assessment of NaB. However, it should be prudent on using NaB chronically, particularly in a large amount, because the stable harmful adducts remained quite long even after a single low dose exposure.
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