Benzo[a]chinolizine, eine neue K�rperklasse mit Wirkung auf den 5-Hydroxytryptamin- und Noradrenalin-Stoffwechsel des Gehirns

Abstract

Various new synthetic derivatives of 1,2,3,4,6,7-hexahydro-benzo[a]-quinolizine have been described. These substances show the following biological properties: a) In animals they cause a decrease in the brain content of 5-hydroxytryptamine (5HT) and norepinephrine (NA). The intensity and duration of action of the various derivatives are different, but less than in the case of reserpine. b) The urinary excretion of 5-hydroxyindole acetic acid is increased by about 200% after administration of Ro 1-9569, the compound with the longest duration of action in the series. c) Various benzoquinolizine derivatives cause sedation without hypnosis, and potentiation of ethanol narcosis in mice. d) After pretreatment with iproniazid the benzoquinolizine-induced decrease of 5HT and NA in brain as well as the benzoquinolizine-induced potentiation of ethanol narcosis in mice is diminished. In rabbits after pretreatment with iproniazid the benzoquinolizines no longer cause sedation, miosis and hypothermia, but muscular tremor, piloerection, mydriasis and hyperthermia. e) There is a parallelism between biochemical alterations and pharmacological actions after administration of various benzoquinolizine derivatives and reserpine.