Abstract
The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although, with the benefit of increased diagnostic techniques and improved understanding, these structures are attracting greater attention in additional research settings, including applications as organic radicals and semiconductors. In addition, the benzodithiazole functionality has been shown to be a valuable synthetic intermediate in the preparation of a variety of other privileged aromatic and heteroaromatic targets, many of which are important APIs. In this review, the authors aim to critically analyse the potential applicability of these compounds to the fields of not only small-scale laboratory synthetic and medicinal chemistry but also commercial-scale processes and increasingly materials chemistry.
Highlights
The procedure works best when applied towards ortho aminonaphthaleneconditions not have optimised or fully investigated, theon process wasscales favoured at the time may as a means to been rapidly synthesise
Fourteen different benzothiazole-secondary amines (18a–n) have been generated from five different benzo-1,2,3-dithiazole 2-oxides (17a–e, Table 2); the yield varied widely, with some being as low as 8%, though there is no indication that the process was optimised
The reactions were performed in a medium of acetic acid, and the products were isolated by filtration and, in many cases, were crystalline
Summary
Alexander J. R.R. ** Correspondence: Citation: Nicholls, A.J.; Baxendale, I.R. Benzo[1,2,3]dithiazole I.R. Applicability in and Their Renewed Applicability in Synthetic Chemistry, Materials Reaction. Originating from the Herz Reaction. Yu. Published: Publisher’s Note: MDPI stays neuPublisher’s Note: MDPI stays neutral tral with regard to jurisdictional with regard to jurisdictional claims in claims in published maps and institupublished maps and institutional affiltional affiliations. iations. Abstract: unique heteroaromatic heteroaromatic functionality functionality whose whose conjugated conjugated
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