Abstract
Aim: Neuroblastoma is one of the leading tumors among the childhood cancers and the treatment of the disease is currently being investigated. As the metastatic ability of the cells is high, current anticancer therapy needs improvement. 
 Method: Therefore, here five novel benzimidazole-thiazole compounds were synthesized. Their strucutres were elucidated using spectroscopic methods like FTIR, NMR and Mass analysis. The synthesis monitoring and purity of the compounds were performed with chromatographic methods. The compounds biological activity on SH-SY5Y neuroblastoma cell line was investigated using MTT assay. 
 Results: All of the tested compounds showed moderate cytotoxic activity. The best IC50 was obtained from compound 6b with the IC50 value of 175,02±4,17 µM. 
 Conclusion: These results indicated that benzimidazole-thiazole core is important for anti neuroblastoma activity, however, the ability of intramolecular hydrogen bonding could block the anticancer activity.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
