Abstract

A 6-week, parallel, randomized, open-label study was conducted to evaluate the effects of bentazepam 75 mg/day versus those of clorazepate 30 mg/day in 50 patients with anxiety disorders. Both drugs reduced anxiety as measured by the Hamilton Anxiety Scale (HAS) and the State-Trait Anxiety Inventory (STAI). The mean HAS and STAI scores at weeks 1, 3, and 6 in patients receiving bentazepam were significantly lower than those of patients receiving clorazepate. Patients taking bentazepam also exhibited improved performance on cognitive tests (Digit-Symbol Substitution Test and Digit Span). Although further studies are needed, bentazepam seems to differ from classic benzodiazepines with regard to its effects on cognitive function.

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