Abstract
Purpose We assessed the relationship between changes in scores for the American Urological Association (AUA) symptom index and benign prostatic hyperplasia (BPH) impact index with patient global ratings of improvement in a large Veterans Affairs trial comparing different pharmacological therapies for BPH. Materials and Methods The primary analyses compared absolute score changes from baseline with global ratings of improvement at 13 weeks for 1,218 men. Results Subjects who rated themselves as being slightly improved had a mean decrease in AUA symptom index and BPH impact index scores of 3.1 and 0.4 points, respectively. However, the baseline scores strongly influenced this relationship. Conclusions These data provide guidance for investigators using the AUA symptom index and BPH impact index as outcome measures.
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