Benign Multicystic Peritoneal Mesothelioma: A Rare Condition in an Uncommon Gender.

Muhammad S Khurram,Hamadullah Shaikh,Ameer Hamza,Tarik Hadid,Awais Zaka,Jacob Edens,Roohi Bano,Uqba Khan,Warda Ibrar

doi:10.1155/2017/9752908

Abstract

Benign Multicystic Peritoneal Mesothelioma (BMPM) is a rare condition that arises from the abdominal peritoneum. Fewer than 200 cases have been reported worldwide. BMPM usually affects premenopausal women and is extremely rare in men. Many factors are suspected to contribute to its development, such as previous surgery, endometriosis, and familial Mediterranean fever. The main management is surgical resection; however, it is estimated that the recurrence rate is up to 50%. Malignant transformation is rare. We report a case series of three male patients who were diagnosed with BMPM and were treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).

Highlights

Benign Multicystic Peritoneal Mesothelioma is a rare benign tumor that presents with recurrent peritoneal mesothelial cysts that arise from the epithelial and mesenchymal elements of mesothelial tissue
Some authors believe that Benign Multicystic Peritoneal Mesothelioma (BMPM) derives from chronic inflammatory processes involving the peritoneum, which results in a reactive hyperplastic and dysplastic transformation of mesothelial cells
Despite the lack of universal consensus, most authors adopt the first theory in which chronic peritoneal inflammation occurs, which results in proliferation and migration of peripheral mesothelial cells often associated with metaplasia of the underlying connective tissues [9,10,11]

Summary

Introduction

Benign Multicystic Peritoneal Mesothelioma is a rare benign tumor that presents with recurrent peritoneal mesothelial cysts that arise from the epithelial and mesenchymal elements of mesothelial tissue. It has an extremely low potential of transformation to malignant mesothelioma. One case report, published by Curgunlu et al [7], describes a man with familial Mediterranean fever who developed. The mean age in male patients in our case series is 67 years. As the disease is rarely reported in males, the variation in mean age between male and female patients needs to be determined [1, 3, 6]

Clinical Summary

Pathologic Findings

Discussion