Abstract
There have been no large-scale studies on the epidemiology of benign convulsions with mild gastroenteritis (CwG) since the introduction of the rotavirus vaccine in South Korea in 2007. This study aimed to analyze the trends in rotavirus gastroenteritis (RVGE) and rotavirus-associated CwG (RaCwG) after rotavirus vaccination. Further, we aimed to analyze changes in norovirus gastroenteritis (NVGE) and norovirus-associated CwG (NaCwG) using nationwide data from the Korean Health Insurance Review and Assessment Service. Between 2007 and 2019, this study analyzed children aged <6 years who were diagnosed with RVGE, NVGE, RaCwG and NaCwG. The changes in the prevalence of each disease and the ratio of CwG to enteritis were analyzed and the effects of age, sex and season were also analyzed. RVGE, RaCwG, NVGE and NaCwG were diagnosed in 273,898, 4246, 35,593 and 337 patients, respectively. The prevalence of RVGE was on a decreasing trend every year, but the prevalence of NaCwG and NVGE was on an increasing trend. There was a significant annual increase in the ratio of CwG to enteritis in both viruses. In order to control the prevalence of RaCwG, measures other than the rotavirus vaccine are required and measures to prevent norovirus are necessary.
Highlights
More than 100 million individuals present with infectious enteritis with some children requiring hospitalization
Rotavirus and norovirus, which are the major causes of infectious enteritis, are responsible for 520,000 and 200,000 annual deaths, respectively, in children aged
Numerous convulsions with mild gastroenteritis (CwG) cases are accompanied by rotavirus infection [10,24]
Summary
More than 100 million individuals present with infectious enteritis with some children requiring hospitalization. Rotavirus and norovirus, which are the major causes of infectious enteritis, are responsible for 520,000 and 200,000 annual deaths, respectively, in children aged
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