Abstract
Background. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results following initial AUS/FLUS diagnoses. Methods. From December 2009 to February 2011, a total of 114 nodules in 114 patients diagnosed as benign on follow-up fine-needle aspiration (FNA) after AUS/FLUS results were included in our study. Eight among 114 nodules were confirmed pathologically and 106 were clinically observed by a follow-up FNA or US. Suspicious US features were defined as markedly hypoechogenicity, irregular or microlobulated margin, presence of microcalcifications, and taller than wide shape. Results. There were 110 (96.5%) benign nodules and 4 (3.5%) malignant nodules. Two (4.8%) among 42 nodules without suspicious US features and 2 (2.8%) out of 72 nodules with suspicious US features were confirmed as malignancy, but there were no significant associations between the malignancy rate and US features (P = 0.625). Conclusion. Clinical follow-up instead of surgical excision or continuous repeat FNA may be enough for benign thyroid nodules after AUS/FLUS. The role of US features might be insignificant in the management of these nodules.
Highlights
Fine-needle aspiration (FNA) is a useful test for thyroid nodule evaluation and has been widely accepted as the main diagnostic procedure [1,2,3]
A uniform classification scheme was proposed with 6 distinct diagnostic categories in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference and led to the subsequent Bethesda system for Reporting Thyroid Cytopathology [3, 7,8,9]
The rate of AUS/FLUS has varied from 1.2% to 17.8% the Bethesda system limits its designation to approximately 7% or fewer of all thyroid fine-needle aspiration (FNA) and an effort should be made to assign this category as little as possible [8, 19,20,21,22,23]
Summary
Fine-needle aspiration (FNA) is a useful test for thyroid nodule evaluation and has been widely accepted as the main diagnostic procedure [1,2,3]. Faquin and Baloch reported that no case was confirmed as malignancy among nodules with initial AUS/FLUS cytology results and benign results in repeat FNA [11]. They regarded repeat FNA as an effective means for definitive management-based diagnosis [11]. Management of thyroid nodules with benign aspirates following atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is not well established. We reviewed the risk of malignancy and the role of ultrasound (US) features among thyroid nodules with benign results following initial AUS/FLUS diagnoses. From December 2009 to February 2011, a total of 114 nodules in 114 patients diagnosed as benign on follow-up fine-needle aspiration (FNA) after AUS/FLUS results were included in our study. The role of US features might be insignificant in the management of these nodules
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