Abstract
The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.
Highlights
Cancer is generally not considered a transmissible disease, direct transmission from one host to another has been documented in rare circumstances
For patients with end-stage renal failure (ESRF), renal transplantation confers improvement in quality of life and survival when compared to dialysis
Our results show that benign and malignant renal cells are differentially inhibited during prolonged organ preservation
Summary
Cancer is generally not considered a transmissible disease, direct transmission from one host to another has been documented in rare circumstances. One such example arises from the immunosuppressive condition following transplantation of a donor organ harboring occult malignancy. The transplant community has since learned that most cancers, including renal cancer, serve as contraindications for organ donation [2]. In the current era of scarce donor organs, a significant number of ESRF patients, especially those with severe medical problems on long-term dialysis, die from the complications of chronic renal insufficiency before they are able to receive a transplant [3]. Usually less than 4 cm in diameter, have low malignant potential; several transplant centers have explored the utilization of donor kidney after resection of small renal cancer [4,5,6,7,8,9,10,11,12,13,14,15]
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