Benign and malignant breast lesions identification through the values derived from shear wave elastography: evidence for the meta-analysis.

Yan Xue,Shuxin Yao,Huarong Zhang,Xiaodong Li

doi:10.18632/oncotarget.21124

Yan Xue, Shuxin Yao + Show 2 more

Open Access

https://doi.org/10.18632/oncotarget.21124

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Journal: Oncotarget	Publication Date: Sep 21, 2017
Citations: 14	License type: cc-by

Affiliation: Linyi People's Hospital, Heze Municipal Hospital

Abstract

ObjectiveThe analysis was aimed to evaluate the diagnostic accuracy of shear wave elastography (SWE) for malignant breast lesions through a meta-analysis.Materials and MethodsRelated articles were searched in databases of Pubmed, Embase and Cochrane library. Overall sensitivity and specificity were analyzed with DerSimonian and Laird random effects model. Area under curve (AUC) with corresponding 95% confidence interval were also analyzed to evaluate the diagnostic accuracy of SWE. P value < 0.05 predicted the significant heterogeneity between study. Sensitivity and publication bias were assessed as well.ResultsAccording to the inclusion criteria, 25 articles were selected. In the subgroup analysis, diagnostic sensitivity and specificity of SWE in Asian population were 0.84 (0.79–0.88) and 0.87 (0.84–0.90), respectively, while they were 0.92 (0.86–0.96) and 0.89 (0.84–0.92) in Caucasian population. The diagnostic accuracy of SWE was a little higher for Caucasians than for Asians (0.95 vs. 0.92). The diagnostic sensitivity and specificity of virtual touch tissue quantification (VTTQ) were 0.85 (0.77–0.91) and 0.93 (0.88–0.96), respectively. It showed a little higher value in specificity and summary receiver operating curve (sROC) than that of SWE (0.93 vs. 0.87; 0.95 vs. 0.93). In addition, maximum stiffness exhibited higher detection sensitivity than that of mean stiffness (0.91 vs. 0.85).ConclusionsSWE serves as an accurate diagnostic technology for discriminating malignant and benign breast lesions.

Highlights

Breast cancer is one of serious diseases threatening health in women and is the major cause of death among women [1, 2]
The analysis was aimed to evaluate the diagnostic accuracy of shear wave elastography (SWE) for malignant breast lesions through a meta-analysis
SWE serves as an accurate diagnostic technology for discriminating malignant and benign breast lesions

Summary

Introduction

Breast cancer is one of serious diseases threatening health in women and is the major cause of death among women [1, 2]. Gray-scale ultrasonography is a valuable adjunct technique It shows highly sensitive detection of benign breast lesions from malignant ones [6,7,8]. The Breast Imaging Reporting and Data System (BI-RADS) along with ultrasonography contribute to understanding the standardized terminology about ultrasonography features, assessments and recommendations [9, 10] This technique is subjective and poorly specific [10,11,12]. Ultrasound elastography emerges as an efficient tool to detect malignant solid lesions through measuring the stiffness It exhibits 86.5% sensitivity, 89.8% specificity and 88.3% accuracy in discriminating benign and malignant breast lesions [13]

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