Abstract
As a promising in vivo tool for cancer research, zebrafish have been widely applied in various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for cancer research that can be established quickly and requires only a small sample size, which makes it favorite among researchers. Zebrafish patient-derived xenograft (zPDX) models provide promising evidence for short-term clinical treatment. In this review, we discuss the characteristics and advantages of zebrafish, such as their transparent and translucent features, the use of vascular fluorescence imaging, the establishment of metastatic and intracranial orthotopic models, individual pharmacokinetics measurements, and tumor microenvironment. Furthermore, we introduce how these characteristics and advantages are applied other in tumor studies. Finally, we discuss the future direction of the use of zebrafish in tumor studies and provide new ideas for the application of it.
Highlights
The implantation of tumors into zebrafish has become an emerging model platform in cancer studies
We focus on applications of the zebrafish model of implanted tumors to facilitate cancer studies and predict the efficacy of personalized cancer treatment
Characteristics of the zebrafish model, such as the establishment of various tumor models, antitumor drug pharmacokinetics, and the tumor microenvironment (TME), are discussed in detail (Figure 1)
Summary
Reviewed by: Rita Fior, Champalimaud Foundation, Portugal Jessica Blackburn, University of Kentucky, United States. Benefits of Zebrafish Xenograft Models in Cancer Research. As a promising in vivo tool for cancer research, zebrafish have been widely applied in various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for cancer research that can be established quickly and requires only a small sample size, which makes it favorite among researchers. Zebrafish patient-derived xenograft (zPDX) models provide promising evidence for short-term clinical treatment. We discuss the characteristics and advantages of zebrafish, such as their transparent and translucent features, the use of vascular fluorescence imaging, the establishment of metastatic and intracranial orthotopic models, individual pharmacokinetics measurements, and tumor microenvironment. We discuss the future direction of the use of zebrafish in tumor studies and provide new ideas for the application of it
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