Abstract
Endometriosis, characterized by macroscopic lesions in the ovaries, is a serious problem for women who desire conception. Damage to the ovarian cortex is inevitable when lesions are removed via surgery, which finally decreases the ovarian reserve, thereby accelerating the transition to the menopausal state. Soon after cessation of ovarian function, in addition to climacteric symptoms, dyslipidemia and osteopenia are known to occur in women aged >50 years. Epidemiologically, there are sex-related differences in the frequencies of dyslipidemia, hypertension, and osteoporosis. Females are more susceptible to these diseases, prevention of which is important for healthy life expectancy. Dyslipidemia and hypertension are associated with the progression of arteriosclerosis, and arteriosclerotic changes in the large and middle blood vessels are one of the main causes of myocardial and cerebral infarctions. Osteoporosis is associated with aberrant fractures in the spine and hip, which may confine the patients to the bed for long durations. Bone resorption is accelerated by activated osteoclasts, and rapid bone remodeling reduces bone mineral density. Resveratrol, a plant-derived molecule that promotes the function and expression of the sirtuin, SIRT1, has been attracting attention, and many reports have shown that resveratrol might exert cardiovascular protective effects. Preclinical reports also indicate that it can prevent bone loss and endometriosis. In this review, I have described the possible protective effects of resveratrol against arteriosclerosis, osteoporosis, and endometriosis because of its wide-ranging functions, including anti-inflammatory and antioxidative stress functions. As ovarian function inevitably declines after 40 years, intake of resveratrol can be beneficial for women with endometriosis aged <40 years.
Highlights
Accepted: 27 October 2021Endometriosis is defined as the growth of the extrauterine endometrial tissue in the presence of estrogen
We will describe how resveratrol can ameliorate the problems of the cardiovascular system, bone mineral density, and endometriosis, and how these positive effects might be associated with the resveratrol-mediated activation of Sirtuin 1 (SIRT1)
A large amount of lipids is deposited between the inner membrane layer and the middle membrane layer, and tissues containing collagens are observed. Cells leaching into this layer are mainly macrophages that are converted into monocytes after they emerge into the inner membrane
Summary
Endometriosis is defined as the growth of the extrauterine endometrial tissue in the presence of estrogen. Estrogen levels in postmenopausal women are lower th function, and in theall presence of endometriosis accelerates the menopausal. It is believed those in men generations. An inevitable decrease that rapid decrease in estrogen is detrimental for the maintenance of women’s health, and ovarian function, and the presence of endometriosis accelerates the menopausal stage that the decrease should be more modest. This theory is known as euestrogenemia [4]. We will describe how resveratrol can ameliorate the problems of the cardiovascular system, bone mineral density, and endometriosis, and how these positive effects might be associated with the resveratrol-mediated activation of SIRT1
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