Abstract

Background: Our objectives are to report the efficacy and safety of intrathecal baclofen (ITB) therapy for the temporary treatment of spasticity and dystonia, and to illustrate the benefit of temporary ITB therapy while patients are in rehabilitation. Methods: This is a retrospective case series of three patients with spasticity and dystonia who were treated with ITB. All patients had their pump and catheter explanted after their movement disorder resolved and their abilities improved, and they were slowly weaned off ITB. Results: ITB therapy prevented the development of complications related to inadequately treated spasticity and dystonia. All patients improved clinically to the extent where the ITB could be tapered off and discontinued. Each patient had their pump and catheter hardware explanted successfully. Conclusions: ITB therapy is effective in decreasing complications associated with hypertonicity and spastic dystonia. Removal of hardware is feasible for patients with clinical improvement after careful, decreasing titration of baclofen thereby avoiding withdrawal symptoms.

Highlights

  • Spasticity and dystonia may develop as a consequence of brain or spinal cord injury (SCI) [1,2,3,4,5,6,7,8]

  • There may be some degree of plasticity of the brain to reassign functional capacities that may be retained into young adulthood

  • This gamma aminobutyric acid B (GABAB) receptor agonist acts in the dorsal horn of the spinal cord and causes an inhibitory influence on the alpha motor neurons [2,10,11,12,13,14,15]

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Summary

Introduction

Spasticity and dystonia may develop as a consequence of brain or spinal cord injury (SCI) [1,2,3,4,5,6,7,8]. Baclofen is a muscle relaxant medication used for the treatment of patients diagnosed with spasticity and dystonia [9]. This gamma aminobutyric acid B (GABAB) receptor agonist acts in the dorsal horn of the spinal cord and causes an inhibitory influence on the alpha motor neurons [2,10,11,12,13,14,15]. Our objectives are to report the efficacy and safety of intrathecal baclofen (ITB) therapy for the temporary treatment of spasticity and dystonia, and to illustrate the benefit of temporary ITB therapy while patients are in rehabilitation

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