Abstract
Aim: Studying the effects of self-paced concurrent high-intensity interval training and resistance training (HIIT-RT) on respiratory function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis (PwMS).Methods: Twenty-three PwMS were randomized into a 12-week training group (three times per week) (TG, n=11) or a control group (CG, n=12). Lung function (spirometry), aerobic capacity (graded cardiopulmonary-exercise-testing) and perceived fatigue (Fatigue Severity Scale (FSS)) were evaluated pre- and post-intervention.Results: The forced vital capacity (p=0.036, Hedges'g (g)=0.93), forced expiratory time (p=0.045, g=0.88), peak expiratory flow (p=0.043, g=0.89) increased in TG compared with CG. The TG showed an increase in peak aerobic power (p=0.004, g=1.34) and peak oxygen uptake (p<0.001, g=2.58) compared with CG. There was a decrease in ventilatory equivalent for carbon dioxide (p=0.02, g=1.02) and FSS scores (p<0.001, g=1.72) in TG comparatively with CG.Conclusion: 12-week self-paced HIIT-RT enhanced lung function as well as aerobic fitness, and alleviated fatigue perception in PwMS.
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