Abstract
August 2015 e11 −3.5 to 11.7; 26.8; CI, 17.6 to 36.8, respectively), a subjective visual analogue scale for alertness (−1.3; CI, −3.7 to 1.2; −2.5; CI, −4.8 to −0.2; −5.3; CI, −7.7 to −2.9, respectively) and saccadic peak velocity (−14.3; CI, 33.5 to 4.8; −10.9; CI, −29.0 to 7.1; −25.4 (CI, −44.2 to −6.6, respectively), a marker for sedation. Mecamylamine was well tolerated and had linear pharmacokinetics over the dose range tested. Conclusion: The pharmacological challenge model with mecamylamine 20 mg in healthy subjects leads to a reproducible pattern of cognitive disturbance that is nicotinic receptor specific. This model may be more suitable for proof of pharmacology and dose finding studies of nicotinic receptor agonists than the frequently used scopolamine model.
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