Abstract
Chronic diarrhea is a common complication of immunodeficiency syndromes.1 Although this may be due to infection with specific enteric pathogens or may be the result of bacterial overgrowth, often the exact cause is unclear. Antibiotic therapy and replacement of immunoglobulin intramuscularly or intravenously remain the mainstays of management of humoral immunodeficiency syndromes. 2 However, these modalities of therapy frequently fail to improve the chronic gastrointestinal symptoms. Assuming that chronic diarrhea in patients with humoral immunodeficiency is caused by infectious agents, we have elected to treat such patients with oral IgG. Our choice was based on previous reports that indicated a beneficial effect of orally administered immune globulin preparations in treating rotavirus infection 3 and in preventing necrotizing enterocolitis 4 in premature infants. We describe our experience with a preparation containing IgG to treat two children with chronic diarrhea; one patient had selective IgA deficiency, and the other had common variable hypogam
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