Abstract
Purpose This study tested the hypothesis that combined therapy with and colchicine is superior to either alone in attenuating monocrotaline (MCT)-induced rat pulmonary arterial hypertension (PAH). Methods and Materials Adult male Sprague-Dawley rats (n=50) were equally randomized into group 1 (sham control), group 2 [MCT (60 mg/kg i.p.)], group 3 [MCT-Nicorandil; (5.0 mg/kg/day)], group 4 [MCT-Colchicine (1.0 mg/kg/day)], and group 5; (MCT-Nicorandil-Colchicine). Drugs were given on day 5. All animals were hemodynamically assessed on day 90 after MCT administration and then were euthanized with the hearts and lungs harvested for morphometric studies, and for protein and mRNA analyses. Results Right ventricular systolic blood pressure (RVSBP) and RV weight were increased in group 2 compared to group 1, reduced in groups 3 and 4 compared to group 2, and further reduced in group 5, whereas arterial-oxygen saturation showed an opposite pattern (all p Conclusions Combined therapy with nicorandil and colchicine is superior to either alone in attenuating MCT-induced PAH in rats.
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