Benefit Effect of Sublingual Dust Mite Drops on the Control of Asthma in Children.

Abstract

AimTo evaluate the effect of sublingual dust mite drops on inhaled corticosteroid replacement and its effect on asthma control level.MethodsTwo hundred children with asthma who had received regular treatment for one year or more were divided into the observation group (71 cases) and control group (89 cases) according to whether sublingual dust mite drops were added on the basis of conventional treatment drugs. After treatment, C-ACT score, VAS score, drug score, lung function, exhaled nitric oxide level, and “ICS avoidance” were compared between the two groups.ResultsBefore treatment, FVC and PEF25 scores in the observation group were lower than those in the control group, and the difference was statistically significant. There was no significant difference in other indicators between the two groups. There was no statistical significance in each index between the single allergic group and the multiple allergic group. Both the observation group and the control group showed statistically significant differences in each index before and after treatment. C-ACT score, FVC, FEV1, PEF, PEF75, PEF50, PEF25, MMEF75/MMEF25 after treatment were all higher than before treatment in both groups; VAS score, drug score and FeNO after treatment were all lower than before treatment. Except PEF, the difference between the observation group and the control group before and after treatment was statistically significant. Among them, after treatment, the increased values of C-ACT, FVC, FEV1, PEF75, PEF50, PEF25, MMEF75/MMEF25 in the observation group were higher than those in the control group, while the decreased values of VAS score, drug score and FeNO were higher than those in the control group. The differences were statistically significant. After treatment, the increased value of FEV1 in the single allergic group was higher than that in the multiple allergic group, and the difference was statistically significant. There was no statistical significance in the changes in other indexes between the two groups before and after treatment. The ICS avoidance rate in the observation group was 57.4% (58/100), higher than that in the control group (17.0%, 17/100), and the difference was statistically significant (χ2=35.108, P < 0.01). The ICS avoidance rate was 55.6% (15/27) in the single allergic group and 58.1% (43/74) in the multiple allergic group, and there was no significant difference between the two groups (χ2=0.053, P=0.818).ConclusionSublingual dust mite drops can significantly improve the asthma control levels in children with asthma and have the effect of inhaled corticosteroid replacement.