Abstract
Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high availability, and relative simplicity of acquisition, it is the object of inexhaustible interest of scientists. This review summarizes scientific reports concerning the possible application of bromelain in treating cardiovascular diseases, blood coagulation and fibrinolysis disorders, infectious diseases, inflammation-associated diseases, and many types of cancer. However, for the proper application of such multi-action activities of bromelain, further exploration of the mechanism of its action is needed. It is supposed that the anti-viral, anti-inflammatory, cardioprotective and anti-coagulatory activity of bromelain may become a complementary therapy for COVID-19 and post-COVID-19 patients. During the irrepressible spread of novel variants of the SARS-CoV-2 virus, such beneficial properties of this biomolecule might help prevent escalation and the progression of the COVID-19 disease.
Highlights
Despite the significant development of modern medicine in many fields such as microbiology, chemotherapy, or cardiology, we are still struggling with the serious problem of the selectivity of the used compounds
This review was based on literature collected by searching the PubMed database of the National Library of Medicine using the following keywords: “bromelain” or “bromelain” and “cancer”, “inflammation”, “cardiovascular diseases”, “coagulation”, “fibrinolysis”, “medicine”, “SARS-CoV-2 virus”
Today’s industry draws heavily from benefits offered by bromelain in many fields
Summary
Despite the significant development of modern medicine in many fields such as microbiology, chemotherapy, or cardiology, we are still struggling with the serious problem of the selectivity of the used compounds. A significant increase in interest in plants and the possibility of using natural compounds of plant origin in medicine has been observed. It has been observed that plants are a vital component of our daily diet and an essential source of compounds of natural origin with excellent biological properties. Various medicinal products of plant origin are the foundation of today’s pharmaceutical industry [1]. Due to their high efficiency in many areas of medicine with low side effects, high availability, and relative simplicity of acquisition, we are witnesses to a global revival in the field of interest and use of plant and botanical therapy in health care products [2]
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