Abstract
ObjectiveThe present study aims to evaluate the influence of a hypercaloric diet (HC) diet on the inflammatory and metabolic parameters of mice and the protective effect of probiotics, as well as the possible effects on the offspring. Materials and methodsThe control groups (C, CP, and CPP) received the normocaloric diet – Nuvilab Quimtia® – 3.86kcal/kg. The hypercalorie groups (HC, HCP and HCPP) received the diet accordingly – PragSoluções® – 5.98kcal/kg. The control pregnant probiotic (CPP) and the hypercaloric pregnant probiotic group (HCPP) received the corresponding diet plus probiotics during pregnancy. We carried out metabolic and biometric parameters, inflammation markers, and histological analyses of the liver. ResultsAn increase in the following parameters was found in the F0: adiposity, leptin, energy efficiency coefficient, lower insulin decay rate, and hepatic lipidosis. Interestingly, there was no deposition of fat in the liver of the group fed with hypercaloric died and treated with probiotics, thus not differing from the control-diet group. Maternal overeating promoted altered metabolic parameters of both dams and offspring, demonstrating the metabolic effects of a hypercaloric diet on the F1; conversely, probiotics had beneficial effects in the F1. ConclusionDeleterious effects of a fructose- and lipid-rich diet may be transmitted to the F1; however, probiotic supplementation seems to counteract these consequences.
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