Beneficial Impact of Folic Acid Against Eco-Physiological Toxicity Induced By Potassium Bromate In Male Rats

Abstract

Potassium bromate (KBrO3) used in both the food and cosmetics industry, and a drinking water disinfection. Strong oxidizer KBrO3 has been employed in the milling of flour. It is a substance that is nephrotoxic and carcinogenic. Acute renal failure and the potential for injury to the reproductive systems were both associated with the therapy KBrO3. Food naturally contains folic acid, especially dark green leafy vegetables. The study aimed to investigation the effects of folic acid supplementation on the KBrO3 toxicity. Animals were randomly divided into four groups: group I control; group II received daily potassium bromate administration (200 mg/kg bw); group III received daily folic acid administration (40 mg/kg); and group IV received daily administration of 200 mg/kg potassium bromate and 40 mg/kg folic acid, respectively. Blood samples were examined for levels of creatine kinase (CK-MB), troponin, lactate dehydrogenase, creatinine, urea, luteinizing hormone (LH), testosterone, and follicle-stimulating hormone (FSH). The experimental animals administered by PB had a substantial increase in CK-MB, troponin, LDH, creatinine, urea, and FSH whereas all experimental rats had a drop in LH and testosterone levels in accordance with the toxicity of potassium bromate. The administration of folic acid had a protective effect on the group of rats treated concurrently with potassium bromate and folic acid. . The heart, kidney, and testis tissues underwent histological examinations, which supported the biochemical findings that the heart, kidney, and testis of KBrO3-treated animals had experienced significant extensive damage. In conclusion, these results show that KBrO3 has serious damaging effects on experimental animals and therefore, its use should be avoided. These dangerous effects should stop its use in human being.