Abstract
It has been previously demonstrated in light microscopic and immunohistochemical studies that ovariectomized rats receiving young coconut juice at 100 mL/kg BW showed much better wound healing and improved skin complexion. Nevertheless, it was found that young coconut juice at 100 mL/kg BW/day caused unfavorable side effects, such as glycogen deposition in the liver. Therefore, in the current study, 3 lower doses (10, 20, and 40 mL/kg BW/day) were optimized, and the ultrastructure was further investigated. Compared to normal rats, all the parameters regarding skin changes, including epidermal and dermal thickness, the number of hair follicles, the diameters of collagen fibrils, perimeters, and nuclei of fibroblast and keratinocyte cells, and ultrastructural changes in keratinocyte and fibroblast cells were significantly reduced in ovariectomized rats. Those parameters in the ovariectomized rats were restored to normal by injecting estradiol benzoate or by feeding young coconut juice to the rats, where the effect was found to be dose-related but not in the case of all the parameters. In most cases, a dose of young coconut juiceof 40 mL/kg BW/day was the optimal dose. The results suggest that young coconut juice may be as effective as estradiol benzoate in reducing skin atrophy/aging, probably as a selective estrogen receptor moderator.
Highlights
The skin is the body’s biggest organ
Under light microscopy (LM) and Transmission Electron Microscopy (TEM) examination, the current study discovered that young coconut juice (YCJ) increased skin thickness while preserving fibroblast and keratinocyte cell shape and increasing collagen fibril quantities
We examined a range of research on the effects of a YCJ oral intake on the expression of ERα and ERβ in injured and normal skin [16,18,19], with the goal of determining if it has phytoestrogenic qualities and can operate as a selective estrogen receptor modulators (SERMs)
Summary
The skin is the body’s biggest organ. As it gets older, it starts to degenerate. The skin serves a variety of purposes, including protecting the body, regulating temperature, and acting as a sensory organ [1]. Skin aging is characterized by a loss of elasticity, decreased epidermal thickness, and the degeneration of dermal collagen and elastic fibers, resulting in wrinkles and skin dryness [2]. Hormones have an affinity with the skin. Estrogens influenceskin’swater-holding capacity [3], vascularity [4], pigmentation [5], and elasticity [6], among other skin functions
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