Abstract
It has been recognized that wasting is a strong independent risk factor for mortality in patient with chronic heart failure. Whereas, it was unknown whether the reverse is true; will an increase in lean muscle mass can improve cardiac function in the setting of heart failure? To address this issue, we have generated skeletal muscle-specific, conditional transgenic mice, that can induce the growth of functional skeletal muscle by switching Akt1 signaling on in muscle fibers. Using this inducible transgenic system, we demonstrated that Akt1-mediated skeletal muscle growth attenuates cardiac remodeling after myocardial infarction, and is associated with an increased capillary density in the heart.
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