Abstract
Objective To investigated the effects of whole-body low-magnitude high-frequency vibration (LMHFV), a form of biophysical intervention, on fracture healing. Methods Closed femoral shaft fracture with intramedullary fixation was established in 55 SD rats. Effects of LMHFV treatment on fracture healing were assessed through comparison with the sham control. Assessments included two- and three-dimensional quantification of mineralized callus formation using plain radiography and micro-CT.Mechanical outcomes were checked with four-point-bending tests. Results Radiography as well as micro-CT showed significantly larger amount of mineralized callus in the treatment group, together with a significantly faster remodeling process of the callus into mature bone. The mechanical strength of the healed fracture was significantly greater after 4 weeks of treatment compared with the control. Conclusions LMHFV enhances healing of the closed femoral shaft fracture in rats. Its potential clinical advantages shall be confirmed in the subsequent clinical trials. Key words: Low-magnitude high-frequency vibration; Fracture healing; Callus; Mechanical testing
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