Abstract
Lipo-prostaglandin E1 (PGE1) is a new preparation of PGE1 in which it is bound to lipids to slow PGE1 release and delay its rate of metabolism. We investigated the change of the blood flow on impaired microcirculation of the ischemic gastric tube in pigs after saline, unmodified PGE1, and lipo-PGE1 administration. The gastric tube was constructed using 15 domestic pigs under general anesthesia, and saline, unmodified PGE1, and lipo-PGE1 were infused continuously at a rate of 0.05 microg/kg/min for 10 min. Tissue blood flow (TBF) and the serum PGE1 concentration were analyzed before administration, after administration for 10 min, and 10 min after the end of administration. There were no obvious changes in TBF during the administration of saline. However, TBF during treatment with unmodified PGE1 and lipo-PGE1 was significantly increased to 13.0 +/- 1.3 and 13.9 +/- 1.3 ml/min/100 g, respectively (paired t-test; P < 0.01). Although TBF was significantly decreased to 8.0 +/- 1.0 ml/min/100 g on 10 min after the end of unmodified PGE1 administration (paired t-test; P < 0.01), it was maintained over 10 ml/min/100 g in lipo-PGE1 group. The serum PGE1 concentration during treatment with unmodified PGE1 and lipo-PGE1 was significantly increased to 229 +/- 21 and 225 +/- 9 pg/ml (paired t-test; P < 0.01), however, it was significantly decreased to 59 +/- 5 and 131 +/- 17 pg/ml (paired t-test; P < 0.01), respectively, on 10 min after the end of administration. However, the serum PGE1 concentration in lipo-PGE1 group was significantly higher than that in unmodified PGE1 group (unpaired t-test; P < 0.01). Lipo-PGE1 infusion leads to the objectively measurable improvement and the prolonged action in the blood perfusion of the gastric tube in pigs. Therefore, treatment with lipo-PGE1 infusion can increase TBF at the anastomotic site, and it may be beneficial for preventing anastomotic leakage in boluses for a couple of times a day.
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