Abstract
Objective: the aim of the present study was to determine the effects of ginsenosides-Rb1 (GRb1) on immune function of rats during strenuous physical exercise. Methods: The rats were randomly divided into four groups: one control group and three different doses of GRb1 (25, 50 and 100 mg/kg) treated groups. The animals were intragastrically administered once daily for 28 days. The exhaustive treadmill exercise was conducted on the final day of experimentation, then the spleen and thymus index, and the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) were measured. Results: GRb1 increased the spleen and thymus index in exhaustive exercise rats. GRb1 also increased the levels of serum IgA, IgG and IgM, and decreased the levels of serum IL-1β, IL-6 and TNF-α. Conclusion: GRb1 have beneficial effects on immune function of rats during strenuous physical exercise.
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