Abstract
Objective: To evaluate the anti-stress activity of standardized extract of Fumaria indica (FI) through validated beha-vioral models of rodents followed by estimation of biochemical changes associated with chronic stress. Methods: Fifty percent ethanolic extract of FI used in this study was standardized on its contents of fumaric acid and its conjugates (0.45% and 0.35% respectively). Stressed Charles Foster rats received unpredictable foot shocks (2 mA, 1 hr, 14 days) through electric grid. FI was given orally as 0.3% carboxymethyl cellulose (CMC) suspension in 100, 200 and 400 mg/kg doses. For comparison, Panax ginseng (PG) extract (100 mg/kg, p.o.) was used as standard adaptogen. Incidence of gastric ulceration, changes in weight of adrenal and spleen, behavioral depression, cognitive dysfunction test and suppression of sexual behavior in male rats were used as validated behavioral models. Plasma corticosterone, brain levels of lipid peroxides (LPO), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), and expression of cytokines IL-1β, TNF-α and IL-10 in circulating white blood cells (WBC) were quantified for ascertaining biochemical changes accompanying stress. Results: As compared to vehicle treated stressed rats, the FI and PG treated rats showed fewer incidence of gastric ulceration, reversal of changes in weight of adrenal gland and spleen, reversal of behavioral depression, better performance in passive and active avoidance tests for cognitive function and increased sexual activity. FI and PG significantly decreased chronic unpredictable stress induced elevation of corticosterone, and both extracts normalized also the abnormal oxidative status of the brain observed in stressed rats. FI treatment also suppressed the elevated level of IL-1β, TNF-α and IL-10 in stressed animals. Conclusions: FI could be another adaptogenic herb and fumaric acid and its conjugates are possibly involved in observed bioactivity of its extract.
Highlights
Fumaria indica Linn. (Syn: Fumaria parviflora, Fumariaceae) is a wildly growing weed found throughout India and many other parts of the globe
To evaluate the anti-stress activity of standardized extract of Fumaria indica (FI) through validated behavioral models of rodents followed by estimation of biochemical changes associated with chronic stress
During the 14 days of chronic stress the vehicle treated rats lost their body weights, whereas weight gains were observed in the unstressed vehicle treated ones
Summary
Fumaria indica Linn. (Syn: Fumaria parviflora, Fumariaceae) is a wildly growing weed found throughout India and many other parts of the globe. (Syn: Fumaria parviflora, Fumariaceae) is a wildly growing weed found throughout India and many other parts of the globe. Due to its allelopathic effects on industrial crops and its potential beneficial effects as animal feed, it is attracting considerable attractions of modern agricultural and veterinary researchers. It is known since long to be a medicinal plant to the practitioners of Ayurvedic and Unani systems of medicine [1]. It is a common ingredient in several herbal preparations currently commercialized in
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
