Abstract
Prebiotics have been shown to improve absorption of some nutrients, including vitamins. This pilot study evaluated the effect of the prebiotic oligofructose-enriched inulin (Synergy 1) on fat-soluble vitamins status, parathormone, and calcium-related elements in pediatric celiac disease (CD) patients (n = 34) on a strict gluten-free diet (GFD). Participants were randomized into a group receiving 10 g of Synergy 1 or placebo (maltodextrin) together with a GFD. At baseline and after 3 months of intervention, 25-hydroxyvitamin D [25(OH)D], parathormone, vitamin E and A, calcium, phosphate, magnesium, total protein, and albumin were determined. Concentration of 25(OH)D increased significantly (p < 0.05) by 42% in CD patients receiving Synergy 1 in GFD, whereas no change was observed in placebo. Vitamin D status reached an optimal level in 46% of patients receiving Synergy 1. No significant difference in parathormone, calcium, and phosphate levels was observed. Concentration of vitamin E increased significantly (p < 0.05) by 19% in patients receiving Synergy 1, but not in the placebo. Vitamin A levels were not changed. Supplementation of GFD with Synergy 1 improved vitamin D and vitamin E status in children and adolescents with CD and could be considered a novel complementary method of management of fat-soluble vitamins deficiency in pediatric CD patients.
Highlights
Over the previous decades, the role of vitamins in the prevention or treatment of diseases has been acknowledged [1]
Vitamin D deficiency can lead to serious consequences, including impairment of bone mineralization; metabolic syndrome; autoimmune disorders; and psychiatric, neurological, and cardiovascular
Vitamin D status is inversely correlated with the incidence of many diseases including cancers, cardiovascular diseases, and neurodegenerative diseases [3,4]
Summary
The role of vitamins in the prevention or treatment of diseases has been acknowledged [1]. The general classification of vitamins is based on their solubility in water or fats. Fat-soluble vitamins include vitamins A, D, E, and K. Vitamins A and E have antioxidant and anti-inflammatory activity, while vitamins D and K are among others involved in bone metabolism [2]. Vitamin D deficiency can lead to serious consequences, including impairment of bone mineralization; metabolic syndrome; autoimmune disorders; and psychiatric, neurological, and cardiovascular. Vitamin D status is inversely correlated with the incidence of many diseases including cancers, cardiovascular diseases, and neurodegenerative diseases [3,4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
