Abstract
Introduction: Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C and E against lead affects lipid hydroperoxide level and liver functions in male rats has been studied. Results: Administration of lead acetate (2%) in dirinking water for 3 months elevates plasma lipid hydroperoxide level, activities of aspartate aminotronsferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), cholesterol, triglycerides and low density lipoprotein (LDL) levels. On the other hand, reduced plasma glutathione (GSH), protein and high density lipoprotein (HDL) concentrations lowered significantly in lead (Pb) treated group. However, oral administration of vitamin C (Vit C) or vitamin E (Vit E) at dose level of 100 mg/kg body weight reduced the alterations in the previous parameters. On the other hand, co-administration of both vitamins (Vit C+ Vit E) to lead-treated rats led to the most significant decline in lipid hydroperoxide level, restoration of GSH level and exhibited more protection as compared with Vit C or Vit E separately. Conclusion: There is synergistic antioxidative effect between Vit C and Vit E that protects the liver from lead induced lipid peroxidation, suggesting that the antioxidant treatment may best be done using a balanced cocktail. .
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