Abstract
The aim of this review was to provide an updated overview of studies on the medical-biological activities of Cinnamomum osmophloeum (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.
Highlights
Cinnamon plants (Cinnamomum spp.) are of the genus Lauraceae, native to South and SoutheastAsia, and are generally used as food flavors and traditional medicinal plants
Irrelevant articles involved studies not related to medical uses, uses, studies related to mushroom planting in C. osmophloeum, and review article(s) (Figure 1)
In vitro and animal studies have revealed the various medical-biological activities of C. osmophloeum encompassing anti-inflammatory, antibacterial, antioxidant, anti-tumor and anticancer, anti-hyperglycemic, anti-hyperuricemia, and antidyslipidemic activities and the effect on the cardiovascular system that have been used for renal disease therapy
Summary
Cinnamon plants (Cinnamomum spp.) are of the genus Lauraceae, native to South and Southeast. Are generally used as food flavors and traditional medicinal plants. Cinnamomum osmophloeum, commonly known as indigenous cinnamon or pseudocinnamon, is endemic to Taiwan’s natural hardwood forests [1]. Major components of the essential oils extracted from. C. osmophloeum leaves explored by high-performance liquid chromatography (HPLC) are as follows: α-pinene, camphene, benzaldehyde, β-pinene, 3-pheayl pionaldehyde, cis-cinnamaldehyde, trans-cinnamaldehyde, isobornylacetate, eugenol, and cinnamil acetate [2]. The essential oils extracted from C. osmophloeum leaves comprise 101 volatile compounds, as identified by GC/MS analysis, including monoterpenoids, sesquiterpenoids, alcohols, phenols, aldehydes, ketones, esters, acids, and other miscellaneous compounds. It was demonstrated that the linalool chemotypes present. Biomedicines 2020, 8, 3 in C. osmophloeum were as follows: linalool, trans-cinnamyl acetate, camphor, cinnamaldehyde, 3-phenyl-2-propenal, caryophyllene, coumarin, bornyl acetate, limonene, α-(+)-pinene, estragole, and caryophyllene oxide [3]. In several studies (both in vitro and in vivo), C. osmophloeum has been applied as an alternative natural therapy to treat certain compromised and uncompromised diseases [3–7]
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