Abstract

In 1993, I was a PhD student at the University of British Columbia, doing research with Leah Edelstein-Keshet, the eminent mathematical biologist. We were very interested in the general problem of alignment of elongated objects in biology—for example, alignment of fish swimming in groups—but really, we were thinking more about angular order in the dynamic cytoskeleton. Electron micrographs of actin filaments (1) in the “comet tail” of actin propelling Listeria pathogens inside host cells fascinated us, and we started to develop a rather abstract mathematical model for the actin filament alignment.

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