Abstract
BackgroundThis study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model.MethodsA total of 72 Wistar male rats were randomly divided into three groups: normal control (NC), DN group and BH treatment (BH) groups. The DN model was induced by streptozotocin (STZ). Weight, glucose, proteinuria, biochemical indicators and the kidney weight index were examined at 8, 12 and 16 weeks. In addition, ANGPTL-4 protein and mRNA expressions were assessed by immunohistochemistry and qRT-PCR, respectively. Relationships between ANGPTL-4 and biochemical indicators were investigated using Spearman analysis.ResultsWeight was significantly lower but glucose levels were significantly higher in both the DN and BH groups than in the NC group (P < 0.05). Compared with the DN group, proteinuria, urea, creatinine, triglycerides and total cholesterol levels were decreased, whereas the albumin level was increased after BH treatment (all P < 0.05). Furthermore, BH diminished kidney volume and ameliorated the pathological changes associated with DN. ANGPTL-4 expression was significantly decreased after BH treatment, and ANGPTL-4 expression was highly correlated with biochemical indicators of DN (P < 0.05).ConclusionsBenazepril hydrochloride improves DN and decreases proteinuria by decreasing ANGPTL-4 expression.
Highlights
This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model
DN incidence is increasing with the rapid growth of diabetes year by year, and DN has become a major cause of endstage renal disease (ESRD) [3]
Significant differences were found between the DN and BH groups at 16 weeks (P < 0.05), but not at 8 and 12 weeks (P > 0.05)
Summary
This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model. Diabetic nephropathy (DN) is one of the major chronic microvascular complications of diabetes, which seriously impacts a large number of people worldwide [1, 2]. DN incidence is increasing with the rapid growth of diabetes year by year, and DN has become a major cause of endstage renal disease (ESRD) [3]. Rapid growth in the incidence of diabetes is occurring in China and other developing countries, leading to a heavy social and economic burden. Proteinuria levels further increase and eventually leads to kidney failure. Proteinuria is a marker for DN severity but is closely associated with DN progression
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