Abstract
The mass spectrometer is a mass-flow-sensitive detector. Improvement of the detection limit in target compound analysis can be obtained by increasing the analyte mass-flow into the spectromer. This can be achieved by applying peak compression methods. Belt-speed programming is a peak compression method that can be applied with the moving-belt interface for liquid chromatography—mass spectrometery. Peak compression is obtained by increasing the belt speed after the deposition of a chromatographic peak on to belt. This paper describes preliminary results of belt-speed programming in both liquid chromatography—mass spectrometry and supercritical-fluid chromatography—mass spectrometry, with the latter case being the most effective. At present, the gain in mass flow is limited by the belt speed range available with the interface by the inefficiency of the thermal desorption process.
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