Belief about medicines in patients with treatment-resistant depression and its influencing factors

Abstract

Objective To explore the belief about medicines in patients with treatment-resistant depression (TRD) and its influencing factors. Methods 106 patients with TRD were recruited to complete the survey of demographic characteristics, Hamilton Depression Scale-17 (HAMD-17) and belief about Medicine Questionnaire-Specific (BMQ-S). Results ①The score of BMQ-s was higher in TRD patients with medical insurance than that of patients with self-funded(rural social insurance(1.11±0.96), medical insurance(0.84±1.33), self expense(0.13±1.72), F=2.81, P<0.01). The score of BMQ-s was higher in TRD patients with serious depression than that of patients with mild to moderate depression((1.07±1.19), (0.34±1.41), t=2.77, P<0.01). The score of BMQ-s was higher in TRD patients with fewer episodes of depression than that of patients with more episodes of depression (0 time(1.10±0.99), once and twice(0.95±1.31), 3 times and above(0.31±1.56), F=3.42, P<0.05). The score of BMQ-s was higher in TRD patients without stigma than those with stigma((1.03±1.21), (0.34±1.43), t=2.58, P<0.01). The score of BMQ-s was higher in TRD patients with more knowledge about the antidepressant than that of patients with less knowledge (most of understanding(1.21±1.09), part of understanding(0.54±1.32), hardly understanding(0.33±1.63), F=3.69, P<0.01). The score of BMQ-s was higher in TRD patients without side effects of antidepressant than those with side effects ((1.04±1.24), (0.19±1.35), t=2.96, P<0.01). ②Stepwise multivariate linear regression analysis showed that payment methods, knowledge about the antidepressant, stigma about the antidepressant and episodes of depression were the influencing factors of BMQ-S in patients with TRD(all P<0.01). Conclusion Different demographic characteristics and clinical features have different beliefs about antidepressant medication in patients with TRD.The payment methods, knowledge about the antidepressant, stigma about the antidepressant and episodes of depression are the influencing factors of BMQ in patients with TRD. Key words: Treatment-resistant depression; Belief about medicines; Treatment compliance; Stigma