Abstract
Intrathecal (i.t.) administration of morphine in the spinal subarachnoid space of mice produced a severe hindlimb scratching response followed by biting and licking. This characteristic behavioural response was inhibited dose-dependently by i.t. co-administration of spantide, a non-selective tachykinin antagonist, [D-Phe 7 , D-His 9 ]substance P (6-11), a selective substance P (SP) antagonist, and sendide, a selective antagonist of neurokinin (NK)-1 receptors. Pretreatment with i.t.-injected antiserum against SP reliably reduced the response to i.t. morphine in a dilution-related manner. The morphine-induced behaviour was also inhibited by pretreatment with i.t.-injected capsaicin, a SP depletor
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