Abstract
The effect of the serotonergic system on psychotic behaviour and sehizophrenia has been recently studied. Meta-chlorophenylpiperazine (MCPP) is a direct-acting 5HT receptor agonist which has been shown to have both neurochemical and behavioural effects in schizophrenic subjects. In this study, we report the behavioural effect of I.V. MCPP administration in a cohort of new-onset and chronic schizophrenics. clozapine trial. Patients were rated for the presence of psychopathological and tardive dyskinesia at regular intervals. Plasma and cerebrospinal fluid homovanillic acid (pHVA, CSF HVA) and cerebrospinal 5hydroxyindoleacetic acid (CSF SHIAA) levels were collected at baseline and treatment week 3. Data from 19 DSM III schizophrenic and schizoaffective disorder patients were examined. The sample was 68% male, 88% treatment refractory, 53% had tardive dyskinesia and the mean age was 29.5k6.3 years. Dividing the sample into clozapine responders vs nonresponders showed that the responders had both a lower baseline CSF HVA levels (pc.08) and a CSF HVA/SHIAA ratio (pi.04). Plasma HVA levels were not associated with CSF HVA values but with CSF SHIAA levels.
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