Abstract
In young chicks with cannulae chronically implanted into the III cerebral ventricle, the effects of BW 245C, a prostaglandin analogue, on behaviour, spectrum power of electrocortical activity and body temperature were studied. Immediately after the administration a dose-dependent behavioural stimulation, i.e. increase in locomotor activity, vocalization, circling and escape responses, was observed; this phase lasted from few minutes to 40 min according to the dose and was followed by a second period of behavioural sedation or sleep. Behavioural stimulation after the higher dose used (5.6 nmol) was accompanied by electrocortical desynchronization, marked decrease in total and 0–4, 4–8 Hz voltage power and hyperthermia whereas during behavioural sedation or sleep electrocortical synchronization was observed without significant changes in spectrum power.
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