Behaviors of stem cells on carbon nanotube.

Ju-Ro Lee,Byung-Soo Kim,Soojin Kim,Seungmi Ryu

doi:10.1186/s40824-014-0024-9

Ju-Ro Lee, Byung-Soo Kim + Show 2 more

Open Access

https://doi.org/10.1186/s40824-014-0024-9

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Abstract

Regulating stem cell microenvironment is one of the essential elements in stem cell culture. Recently, carbon nanotube (CNT) has come into the spotlight as a biomaterial that retains unique properties. Based on its high chemical stability, elasticity, mechanical strength, and electrical conductivity, CNT shows great potential as an application for biomedical substrate. Also, properties of CNT could be further regulated by appropriate chemical modifications of CNT. Recent studies reported that modulating the cellular microenvironment through the use of CNT and chemically modified CNT as cell culture substrates can affect proliferation and differentiation of various types of stem cells. This review summarizes the unique biological effects of CNT on stem cells.

Highlights

Stem cells, which have the ability to self-renew and multipotently differentiate into several phenotypes, have been regarded critical for groundbreaking therapy in the field of regenerative medicine
carbon nanotube (CNT) improved the biocompatibility of the collagen, and it heightened the interaction between the collagen compound Human embryonic stem cell (hESC) cultured on this CNT/collagen composite differentiated into ectodermal lineage in day 3, and into neural lineage in day 6, with enhanced expression of nestin [23]
CNT has emerged as a promising biocompatible substrate among researchers for its unique properties

Summary

Introduction

Stem cells, which have the ability to self-renew and multipotently differentiate into several phenotypes, have been regarded critical for groundbreaking therapy in the field of regenerative medicine. One of the most effective ways to control the fate of stem cells is by changing the properties of the cell culture substrates, which can provide dynamic microenvironmental and morphological cues for stem cell proliferation and differentiation. Review This review briefly outlines the unique characteristics of CNT and highlights the recent applications of CNT for tissue engineering through stem cell differentiation.

Results

Conclusion