Abstract
The behavior of sodium glycochenodeoxycholate (NaGCDC) and sodium glycoursodeoxycholate (NaGUDC) in binary mixed micelles consisting of bile salt and octaoxyethylene glycol mono n-decyl ether (C 10E 8) has been studied on the basis of micellar compositions, polarities of the interior of intramicelles, mean aggregation numbers and 1H NMR measurements. Micellar compositions for both NaGCDCC 10E 8 and NaGUDCC 10E 8 systems showed a tendency to change from C 10E 8-rich micelles to bile-salt-rich micelles with an increase on the mole fraction of bile salts from the results of both theoretical calculations using the critical micelle concentration and the micellar polarity. The microenvironment of intramicelles for the NaGCDCC 10E 8 system was found to be more hydrophobic than that for the NaGUDCC 10E 8 system. Mean aggregation numbers of mixed micelles for both systems decreased abruptly with an increase in the mole fraction of bile salts in the range of low mole fraction, but those for NaGCDC were larger than those for NaGUDC. Furthermore, from the results of 1H NMR measurements, the motions of the methyl group protons in the 18 position of the molecular structure of NaGCDC were slightly restricted with an increase in the mole fraction of NaGCDC. In contrast, the methyl group protons in the 18 and 19 positions of the molecular structure of NaGUDC became freer with an increase in the mole fraction of NaGUDC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.